Tennessee Health Officials Issue Urgent Warning After Cluster of Severe Infections

Tennessee health officials have issued an urgent advisory to clinicians and medical laboratories after identifying a growing cluster of severe infections that have left at least one resident critically ill. The warning follows weeks of investigation into a concerning pattern of serious illness reported in parts of Middle Tennessee, prompting authorities to urge heightened vigilance among health care providers.

The Tennessee Department of Health (TDH) released the alert through its Health Alert Network earlier this month after confirming at least 18 cases of acute and severe illness among residents in Williamson and Maury counties. The cases, which have been reported since September, are concentrated in and around the communities of Spring Hill and Thompson’s Station.

Health officials say the investigation into the source of the outbreak remains ongoing. While no single exposure site has yet been identified, the clustering of cases has raised concerns about environmental factors that may be contributing to the spread of the illness.

According to the advisory, affected patients initially presented with symptoms that closely resemble common respiratory infections. These included persistent fever, cough, shortness of breath, chest pain, headaches, and general fatigue. In several cases, symptoms worsened rapidly, leading to hospitalization and, in the most serious instances, intensive care.

One Nashville-area family has shared the ordeal of their 24-year-old son, who was admitted to hospital in late October after experiencing a high fever and an elevated heart rate. Initial testing suggested pneumonia, but common viral and bacterial causes were ruled out. His condition deteriorated quickly, eventually requiring advanced life support measures, including mechanical ventilation and dialysis. He remains in critical condition.

Midway through the investigation, doctors determined that the illnesses were linked to a serious fungal infection caused by inhalation of airborne spores commonly found in certain soil environments. The infection, which can develop days to weeks after exposure, is known to be associated with areas contaminated by bird or bat droppings. Activities such as clearing brush, demolishing older structures, or working in areas where birds have roosted can increase exposure risk.

While many people exposed to the fungus may experience mild or no symptoms, others—particularly those with weakened immune systems—can develop severe and potentially life-threatening complications. These may include widespread infection affecting the lungs, gastrointestinal tract, skin, liver, spleen, or central nervous system.

The Tennessee Department of Health emphasized that the illness does not spread from person to person. However, officials urged medical professionals to maintain a high level of suspicion when evaluating patients with unexplained fevers or respiratory symptoms, especially in the affected counties.

Clinicians are being asked to promptly report confirmed cases to the department to assist with tracking and containment efforts. Officials stressed that early diagnosis and treatment are critical to improving outcomes.

“At this time, there are at least 18 known cases, and the investigation into the specific source or sources is ongoing,” the advisory stated. Health officials say updates will be provided as more information becomes available, and they continue to work to identify environmental factors that may be driving the rise in cases.

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